Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Treatment Resistent Cancers

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular surveillance of coronaviruses in livestock in northern Vietnam.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2026

Same author

Recent Advances in TiO<sub>2</sub>-Based Photocatalysis for the Treatment of Pesticide-Contaminated Wastewater: Mechanisms, Limitations, and Future Perspectives.

International journal of molecular sciences·2026

Same author

Genome-Wide and Locus-Level Analyses Reveal Modest, Heterogeneous Genetic Sharing Between Alzheimer's Disease and Myasthenia Gravis.

International journal of molecular sciences·2026

Same author

Case Report: Clinical implications of <i>HLA</i>-B*15:02 screening in pediatric patients: a case series from a Thai Binh Children's Hospital, Vietnam.

Frontiers in pediatrics·2026

Same author

Real-world trends in diagnosis, treatment, and survival of non-small cell lung cancer in Vietnam.

BMC cancer·2026

Same author

Development of microbial source tracking markers for detection of human-associated Clostridium perfringens.

Water research·2026

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

First-Line Pembrolizumab Monotherapy for Advanced Non-Small Cell Lung Cancer: A Multicenter Real-World Study from

Thi Huong Pham^1,2, Cam Phuong Pham^3,4,5, Thi Thu Huong Nguyen^1,6

¹Department of Oncology, Hanoi Medical University, Hanoi 100000, Vietnam.

Current Oncology (Toronto, Ont.)

|April 27, 2026

Summary

First-line pembrolizumab monotherapy shows effectiveness and safety in advanced non-small cell lung cancer (NSCLC) patients in Vietnam. Outcomes were favorable in those with high PD-L1 expression and non-squamous histology.

Keywords:

Vietnam advanced stage non-small cell lung cancer pembrolizumab monotherapy

More Related Videos

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions

Published on: July 3, 2025

Related Experiment Videos

Last Updated: Jun 20, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions

Published on: July 3, 2025

Area of Science:

Oncology
Immunotherapy
Clinical Research

Background:

Advanced non-small cell lung cancer (NSCLC) presents significant treatment challenges.
Pembrolizumab monotherapy is a key treatment option for NSCLC.
Real-world data is crucial for understanding treatment effectiveness in diverse settings.

Purpose of the Study:

To evaluate the real-world effectiveness and safety of first-line pembrolizumab monotherapy.
To assess outcomes in Vietnamese patients with advanced NSCLC.
To identify predictors of treatment response and survival.

Main Methods:

Multicenter retrospective cohort study.
Inclusion of patients with locally advanced or metastatic NSCLC receiving first-line pembrolizumab.
Primary endpoints: progression-free survival (PFS), overall survival (OS), and safety profile.

Main Results:

73 patients included; median age 69; 75.3% ECOG PS 0-1; 86.3% PD-L1 TPS ≥ 50%.
Overall response rate 60.3%; disease control rate 79.5%. Median PFS 11.3 months; median OS 25.4 months.
Predictors of inferior OS: never-smoking status, squamous histology, low PD-L1 expression. Grade 3 toxicity in 4.2%.

Conclusions:

First-line pembrolizumab monotherapy is effective and safe for advanced NSCLC in Vietnam.
High PD-L1 expression and non-squamous histology correlated with better survival.
Supports pembrolizumab use in selected populations, even in resource-limited settings.