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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
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Eastern Canadian Gastrointestinal Cancer Consensus Conference 2025.

Arwa Ahmed1, Stéphanie L Mercier1, Ravi Ramjeesingh2

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Eastern Canadian experts met to discuss gastrointestinal (GI) cancer management. Key topics included esophageal, colorectal, and liver cancer treatments and prevention strategies.

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Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • The Eastern Canadian Gastrointestinal Cancer Consensus Conference is an annual meeting.
  • Experts in medical oncology, radiation oncology, nuclear medicine, and general practitioners in oncology (GPO) attended.
  • The conference focuses on the care and management of patients with gastrointestinal malignancies.

Purpose of the Study:

  • To develop a consensus statement on key gastrointestinal cancer topics.
  • To address recent advancements and best practices in GI cancer care.

Main Methods:

  • Annual consensus conference held in Fredericton, New Brunswick.
  • Discussion and deliberation among multidisciplinary oncology experts.
  • Development of a consensus statement based on expert consensus.

Main Results:

  • The consensus statement covers management of early-stage gastroesophageal junction cancer.
  • Recent developments in molecular biomarkers and colorectal cancer treatments are addressed.
  • Secondary prevention strategies for colorectal cancer and hepatocellular carcinoma treatment are included.

Conclusions:

  • The consensus statement provides updated guidance for GI cancer care in Eastern Canada.
  • The meeting facilitated knowledge exchange and collaborative decision-making among experts.
  • The findings aim to improve patient outcomes for gastrointestinal malignancies.