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Ultra-High-Field MRI Morphometry of the Lateral Geniculate Nucleus in Patients with Advanced Visual Loss Due to
Katarzyna Nowomiejska1, Aleksandra Czarnek-Chudzik1, Anna Niedziałek2
1Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland.
Abstract:
Background/Objectives: To investigate the volume of the lateral geniculate nucleus (LGN) in patients with advanced retinitis pigmentosa (RP). Methods: Nineteen patients with advanced RP (mean age 52 years and mean duration of illness 357 months) and twenty-one age-matched normal subjects have been examined using 7 Tesla MRI of the brain. Brain segmentation was carried out with the "recon-all" function in the FreeSurfer software (version 7.4.1) package. Results: The volumes of the left and right LGN were significantly smaller in those patients with RP, in comparison to the controls. We found a significant positive correlation between the volume of the left LGN and the right eye best-corrected visual acuity in the RP group. Conclusions: Late-stage RP leads to a significant reduction in LGN volume, as measured with 7 Tesla MRI. The volume of the left LGN was correlated with the visual function of the right eye in patients with late-stage RP. The statistical power of the results is limited by there being a low number of RP patients included in this study, which is due to the low prevalence of this rare eye disease.
