Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Stellera chamaejasme extract overcomes multidrug resistance in MCF-7 cells through modulation of MEK/ERK pathway].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

Effects of Capsaicin on the Growth, Development, and Nutritional Profiles of Black Soldier Flies Fed a High-Fat Diet.

Insects·2026
Same author

Halogenation engineered metal cluster assemblies.

National science review·2026
Same author

[Research Progress on the Bone Marrow Microenvironment in Beta-Thalassemia --Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same author

Sex-Specific Associations With Abnormal Myocardial Flow Reserve in Non-Obstructive Coronary Artery Disease: Insights From a Real-World Cadmium-Zinc-Telluride SPECT Study.

Clinical cardiology·2026
Same author

[Recent advances in individualized treatment for pediatric high-risk B-cell acute lymphoblastic leukemia].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2026

Related Experiment Video

Updated: Apr 28, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.3K

Divergent Behavioral Phenotypes and Transcriptomic Reprogramming in Lymantria dispar Larvae Infected by Virus,

Lin-Bo Zhai1, Ya-Jie Wang1, Jiang-Bo Zhang2

  • 1Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling 712100, China.

Biology
|April 27, 2026
PubMed
Summary

Different pathogens manipulate host behavior uniquely. A virus (LdMNPV) induced climbing in gypsy moth larvae by altering metabolism and neural pathways, unlike bacteria or fungi.

Keywords:
Lymantria disparbaculovirusbehavioral manipulationcomparative transcriptomicshost–pathogen interactiontree-top disease

More Related Videos

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers
06:58

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Published on: September 29, 2023

1.6K
Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence
09:04

Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence

Published on: December 11, 2012

12.4K

Related Experiment Videos

Last Updated: Apr 28, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
06:02

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

6.3K
Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers
06:58

Author Spotlight: Evaluation of Entomopathogenic Fungi in Wild Monochamus alternatus Populations for Biocontrol Applications in Forest Wood Borers

Published on: September 29, 2023

1.6K
Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence
09:04

Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence

Published on: December 11, 2012

12.4K

Area of Science:

  • Ecology
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Pathogen manipulation of host behavior is a key evolutionary strategy for transmission.
  • Understanding how diverse pathogens affect host behavior and molecular responses in the same host is crucial but poorly understood.

Purpose of the Study:

  • To compare the behavioral and molecular responses of gypsy moth larvae infected with a virus (LdMNPV), bacterium (Staphylococcus aureus), and fungus (Metarhizium anisopliae).
  • To investigate pathogen-specific manipulation strategies and their impact on host physiology and behavior.

Main Methods:

  • Parallel behavioral assays measuring climbing height over 72 hours post-infection.
  • Comparative transcriptomic analyses using RNA-sequencing to profile gene expression at 72 hours post-infection.

Main Results:

  • Only LdMNPV infection led to significant, sustained upward climbing behavior.
  • All pathogens activated Toll and IMD immune pathways, but LdMNPV caused broader transcriptomic reprogramming.
  • LdMNPV uniquely upregulated energy metabolism and neuroactive ligand-receptor interaction pathways, unlike bacterial and fungal infections.

Conclusions:

  • LdMNPV drives tree-top disease via a virus-specific strategy combining metabolic and neural modulation.
  • This study highlights fundamental differences in behavioral manipulation across pathogen kingdoms.
  • Identified candidate pathways for future functional validation of pathogen-host interactions.