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Published on: June 3, 2020

Exploring Early Neurodegeneration Through Fasting-Induced Metabolic Signatures and High-Sensitivity Biomarkers.

Francesco Cacciabaudo¹, Luisa Agnello^1,2, Caterina Maria Gambino^1,2

¹Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, 90127 Palermo, Italy.

Current Issues in Molecular Biology

|April 27, 2026

Summary

Intermittent fasting (IF) may offer neuroprotection by targeting early neurometabolic changes in neurodegenerative diseases (NDs). Advanced biomarkers help monitor IF

Keywords:

intermittent fasting mitochondrial quality control neurodegenerative diseases neuroinflammation neurometabolic pathways precision nutrition ultrasensitive biomarkers

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice

Published on: November 27, 2019

Area of Science:

Neurology
Metabolic Disorders
Biochemistry

Background:

Neurodegenerative diseases (NDs) are increasingly viewed as neurometabolic disorders.
Early signs include mitochondrial dysfunction, neuroinflammation, and synaptic alterations preceding clinical symptoms.

Purpose of the Study:

To review evidence on intermittent fasting (IF) as a neuroprotective strategy for NDs.
To explore the role of advanced biomarkers in monitoring IF's neurometabolic effects.

Main Methods:

Summarized pre-clinical and experimental evidence on IF's impact on early pathogenic processes.
Discussed advances in ultrasensitive biomarker research for early detection of neurodegeneration.
Integrated biomarker data with human and experimental IF studies.

Main Results:

IF may influence early ND pathogenesis via metabolic switching, autophagy, and neuroimmune modulation.
High-sensitivity assays quantify IF's neurometabolic effects and aid early detection.
Precision nutrition and multi-omics profiling can personalize IF protocols.

Conclusions:

Clinical biochemistry integrating advanced biomarkers is crucial for evaluating IF's neuroprotective potential.
IF shows promise as an early intervention for individuals at risk of neurodegeneration.
Personalized nutrition strategies can optimize IF monitoring and response.