Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.

Cell stem cell·2026
Same author

Posterior Arytenoid Cartilage Dislocation Despite Optimal Intubation During Prolonged Steep Trendelenburg Robotic Prostatectomy: A Potential Biomechanical Contributor.

Journal of clinical medicine·2026
Same author

Molecular and Mechanistic Divergence of Seizures in Pediatric Acute Lymphoblastic Leukemia: CNS Infiltration Versus Chemotherapy-Induced Neurotoxicity.

International journal of molecular sciences·2026
Same author

Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows.

International journal of molecular sciences·2026
Same author

Analysis of Factors Affecting Postoperative Opioid Requirement in Adult Patients Undergoing Minimally Invasive Repair of Pectus Excavatum.

Journal of clinical medicine·2026
Same author

Hydrogels and Organogels for Local Anesthetic Delivery: Advances, Challenges, and Translational Perspectives.

Gels (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.6K

Structure-Property-Function Relationships in Stimuli-Responsive Hydrogels for Brain Organoid Vascularization.

Minju Kim1, Hoon Choi1, Woo Sub Yang2

  • 1Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.

Gels (Basel, Switzerland)
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Dynamic hydrogels enhance brain organoid vascularization by mimicking the neurovascular niche. This improves nutrient delivery and maturation for better modeling of neurological disorders.

Keywords:
brain organoidsdynamic biomaterialsneurovascular unitspatiotemporal controlstimuli-responsive hydrogelsstructure–property–function frameworkvascularization

More Related Videos

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

8.0K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

4.5K

Related Experiment Videos

Last Updated: Apr 28, 2026

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

2.6K
A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells
08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

8.0K
Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
10:42

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Published on: June 15, 2021

4.5K

Area of Science:

  • Biomaterials Science
  • Neuroscience
  • Stem Cell Biology

Background:

  • Human induced pluripotent stem cell (iPSC)-derived brain organoids are vital for studying neurodevelopment and disorders.
  • A lack of functional vasculature limits their maturation and physiological relevance.
  • Current extracellular matrix (ECM) mimetics fail to replicate the dynamic neurovascular niche.

Purpose of the Study:

  • To review dynamic hydrogel systems for vascularized brain organoid development.
  • To explore how hydrogel properties influence vascular network formation and maturation.
  • To assess functional outcomes and translational challenges of engineered vascularization.

Main Methods:

  • Discussion of stimuli-responsive hydrogels (photoresponsive, enzyme-cleavable, thermo-responsive, etc.).
  • Analysis of structure-property-function relationships in hydrogel design.
  • Review of evidence from organoid studies and related biomaterial/vascular systems.

Main Results:

  • Dynamic hydrogels offer spatiotemporal control over matrix properties.
  • Hydrogel chemistry and architecture regulate endothelial sprouting, lumen formation, and vascular stabilization.
  • Functional outcomes like improved perfusion and neurovascular unit maturation are achievable.

Conclusions:

  • Dynamic hydrogels are a versatile strategy for vascularizing brain organoids.
  • Stimuli-responsive systems enhance physiological relevance for disease modeling.
  • These platforms advance engineering of vascularized organoids for neurovascular research.