Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lifestyle and Health Characteristics of the Adult Population of Serbia with Type 2 Diabetes Mellitus.

Medicina (Kaunas, Lithuania)·2026

Same author

Trends in Incidence and Mortality of Primary Cutaneous Melanoma in Serbia Between 2008 and 2022.

Medicina (Kaunas, Lithuania)·2026

Same author

Effect of can damage on element migration into meat products during storage and the associated health risks.

Food chemistry·2026

Same author

Dysphonia in Occupational Voice Users: Risk Factors, Causes and Socioepidemiological Profiles.

Medicina (Kaunas, Lithuania)·2026

Same author

Association of Health Literacy with Sociodemographic Factors and Medication Adherence Among Primary Health Care Users in Montenegro.

Healthcare (Basel, Switzerland)·2026

Same author

Examining the Level of Knowledge of Teachers About Asthma, Diabetes and Epilepsy in Children: A Systematic Review.

Children (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Bone Substitutes in Alveolar Ridge Augmentation: A Narrative Literature Review.

Marija Bubalo¹, Sanja Dugonjic², Dejan Dubovina³

¹Clinic for Dentistry, Medical Faculty of the Military Medical Academy, University of Defence, 11000 Belgrade, Serbia.

Journal of Functional Biomaterials

|April 27, 2026

Summary

Alveolar bone grafting is crucial for dental implant success. This review compares bone graft materials for ridge augmentation, highlighting autogenous bone as the gold standard but noting advancements in alternatives for predictable outcomes.

Keywords:

PRF alloplast alveolar ridge augmentation bone graft bone regeneration bone substitute demineralized dentin matrix dental implants guided bone regeneration xenograft

More Related Videos

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

Related Experiment Videos

Last Updated: Jun 30, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

Area of Science:

Dental Implantology
Regenerative Medicine
Biomaterials Science

Background:

Alveolar bone volume is essential for dental implant success.
Post-extraction bone loss often necessitates ridge augmentation.
Guided bone regeneration (GBR) is key in implant dentistry, influenced by graft material properties.

Purpose of the Study:

To review biological principles of alveolar ridge augmentation.
To compare properties and clinical outcomes of common bone graft materials.
To discuss emerging regenerative strategies in implant dentistry.

Main Methods:

Narrative review of literature published between 2000 and 2025.
Analysis of biological principles, graft material properties, and clinical outcomes.
Synthesis of evidence on graft integration, bone formation, resorption, and indications.

Main Results:

Autogenous bone is the gold standard, offering osteogenic, osteoinductive, and osteoconductive potential.
Various alternatives exist, including allografts, xenografts, alloplasts, and scaffolds, each with distinct properties.
No single material is universally ideal; selection depends on defect and clinical goals.

Conclusions:

Appropriate bone graft material selection is critical for predictable implant outcomes.
Future research needs long-term trials, material standardization, and biologically enhanced approaches.
Advancements in biomaterials continue to improve regenerative strategies for alveolar bone defects.