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Biological Effects on S-PRG: An Integrative Review.

Hudson Balthazar Cavalcante de Oliveira^1,2,3, Jessica Zablocki da Luz^2,3, Fabio Eduardo de Lima^2,3

¹Hospital Pequeno Príncipe, Rua Desembargador Motta, 1070, Água Verde, Curitiba 80250-060, PR, Brazil.

Journal of Functional Biomaterials

|April 27, 2026

Summary

This summary is machine-generated.

Surface pre-reacted glass ionomer (S-PRG) materials offer enhanced bioactive properties beyond simple restoration. These advanced dental materials promote tissue repair, mineralization, and possess antimicrobial and anti-inflammatory effects.

Keywords:

S-PRG biological activity biomaterial

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Area of Science:

Dental Material Science
Biomaterials Engineering
Regenerative Dentistry

Background:

Dental restorative materials have evolved from passive replacements to bioactive agents.
Research now focuses on materials that interact beneficially with oral tissues.
Bioactivity aims for disease prevention and tissue repair, not just mechanical function.

Purpose of the Study:

To review the multifunctional bioactive technology of surface pre-reacted glass ionomer (S-PRG) particles.
To synthesize evidence on the biological effects of S-PRG-containing dental materials.
To assess the potential of S-PRG in disease prevention and tissue regeneration.

Main Methods:

An integrative literature review was performed.
Searches were conducted in PubMed, SciELO, and Scopus databases.
Studies evaluating antimicrobial, anti-inflammatory, remineralizing, cellular, or regenerative effects of S-PRG materials were included.

Main Results:

S-PRG particles release multiple ions (F, Sr, B, Na, Si, Al) contributing to their bioactivity.
Evidence supports S-PRG materials' roles in biofilm inhibition and inflammatory modulation.
S-PRG materials demonstrate potential in enhancing mineralization and stimulating cellular repair pathways.

Conclusions:

S-PRG technology represents a multifunctional bioactive system for dental applications.
The biological activity of S-PRG extends to modulating inflammation and promoting tissue repair.
S-PRG materials show promise for developing next-generation restorative and regenerative dental solutions.