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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Candidozyma auris and the Perfect Storm of Fungal Pathogenicity: Adaptation, Persistence, and Resistance

Alessandra Vaccaro1, John F Cooper2, Augusto Vazquez-Rodriguez1

  • 1Department of Molecular Microbiology & Immunology and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA.

Journal of Fungi (Basel, Switzerland)
|April 27, 2026
PubMed

Insights

Candida auris is a dangerous, drug-resistant fungus causing healthcare outbreaks. Its adaptability, like heat tolerance and biofilm formation, drives its spread and resistance, requiring global action.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Candida auris (C. auris) is an emerging multidrug-resistant fungal pathogen.
  • C. auris outbreaks in healthcare facilities lead to poor patient outcomes.
  • Classified as a critical-priority pathogen by CDC and WHO.

Purpose of the Study:

  • To review current knowledge on Candida auris.
  • To summarize its origin, taxonomy, microbiology, and virulence.
  • To highlight antifungal resistance, management, and potential links to climate change.

Main Methods:

  • Literature review of scientific publications.
  • Synthesis of data on C. auris characteristics.
  • Analysis of genomic plasticity and environmental adaptation.

Main Results:

  • C. auris exhibits thermotolerance, osmotolerance, and biofilm formation.
  • Genomic plasticity contributes to its persistence and drug resistance.
  • Climate change may be linked to C. auris evolution and pathogenicity.

Conclusions:

  • Multidrug resistance and adaptability make C. auris a significant global health threat.
  • Multidisciplinary efforts are essential for combating C. auris.
  • Understanding environmental adaptation is key to mitigating its impact.
Keywords:
Candidozyma aurisantifungal drug resistancebiofilmspathogenesis

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