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D2MNet: Difference-Aware Decoupling and Multi-Prompt Learning for Medical Difference Visual Question Answering
Lingge Lai1, Weihua Ou1, Jianping Gou2
1School of Big Data and Computer Science, Guizhou Normal University, Guiyang 550025, China.
Journal of Imaging
|April 27, 2026
Summary
The D2MNet framework improves medical difference visual question answering (Diff-VQA) by analyzing image changes and using multi-prompt learning for better answers. This approach enhances accuracy in identifying and explaining differences in medical images.
Area of Science:
- Medical imaging analysis
- Artificial intelligence in healthcare
- Computer vision
Background:
- Difference visual question answering (Diff-VQA) is crucial for identifying and reasoning about discrepancies in medical images.
- Current Diff-VQA methods struggle with asymmetric descriptions of image changes and lack task-specific guidance for language models.
- Pretrained language decoders require better integration for effective medical image difference analysis.
Purpose of the Study:
- To introduce D2MNet, a novel framework for medical Diff-VQA that integrates change-aware reasoning with prompt-guided answer generation.
- To address limitations in existing methods by improving the modeling of image differences and enhancing language decoder guidance.
- To enhance the accuracy and contextual relevance of answers generated for medical Diff-VQA tasks.
Main Methods:
- Developed D2MNet, incorporating a Change Analysis Module (CAM) for change detection and prompt generation.
- Implemented a Difference-Aware Module (DAM) utilizing dual attention for fine-grained feature extraction.
- Employed a multi-prompt learning mechanism (MLM) to inject diverse prompts into the language decoder for improved generation.
Main Results:
- D2MNet achieved a CIDEr score of 2.907 ± 0.040 on the MIMIC-DiffVQA benchmark.
- The proposed framework significantly outperformed the strongest baseline, ReAl (2.409).
- Experimental results validate the effectiveness of D2MNet's design for medical Diff-VQA.
Conclusions:
- D2MNet demonstrates superior performance in medical Diff-VQA tasks.
- The framework's approach to change-aware reasoning and prompt-guided generation is effective.
- D2MNet shows promise for advancing difference-aware medical answer generation.