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Impaired Oxygen Delivery Risk Analytics in the 6 Hours Before Extracorporeal Membrane Oxygenation: Single-Center
Edon J Rabinowitz1,2,3, Amy Ouyang3,4, Rejean Guerriero4
1Division of Pediatric Critical Care Medicine, Washington University in St Louis, St Louis, MO.
Objectives:
We evaluate the association between pre-extracorporeal membrane oxygenation (ECMO) markers of impaired oxygen delivery, as quantified by the impaired oxygen delivery index (iD o2 ; Etiometry, Boston, MA) and neurologic outcomes in infants supported on ECMO.
Design:
A single-center retrospective cohort study using demographic and clinical data along with iD o2 metrics calculated at 120-minute intervals before ECMO initiation. Primary outcomes included mortality, electroencephalography abnormalities, and head imaging findings. The secondary outcomes included brain MRI abnormalities and Functional Status Score (FSS) at discharge.
Setting:
Pediatric ECMO center in North America.
Patients:
We included infants younger than 1 year old who were supported on ECMO between 2013 and 2017. We excluded cases with congenital diaphragmatic hernia or postcardiac surgery ECMO.
Interventions:
None.
Measurements And Main Results:
We identified 47 infants meeting the inclusion criteria. Median (interquartile range [IQR]) age and weight at ECMO initiation were 16 days (IQR, 6-112 d) and 3.3 kg (IQR, 2.8-4.8 kg). The overall mortality was 26 of 47 (55% [95% CI, 41-69%]). Nonsurvival compared with survival was associated with a greater proportion of patients with congenital heart disease ( p = 0.03) and pre-ECMO cardiac arrest ( p = 0.006). Time spent above iD o2 thresholds of 25%, 50%, and 75% increased closer to ECMO initiation. Higher iD o2 dose correlated with adverse neurologic outcomes, including electroencephalography abnormalities and abnormal imaging. Last, a logistic regression model for poor outcome (composite of death and FSS), including the time spent above the three iD o2 thresholds at the three time intervals pre-ECMO, showed classification model performance with an area under the receiver operating characteristic curve 0.81 (95% CI, 0.7-0.92; p = 0.0002).
Conclusions:
Markers of impaired oxygen delivery, such as iD o2 in the 6 hours before ECMO are associated with subsequent outcome. Incorporation of these metrics into clinical decision-support systems need to be prospectively tested and evaluated.
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