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Trauma-Induced Coagulopathy in Rat Models: Assessing Hemostatic Changes in Mild and Severe Traumatic Brain Injuries
Refat Aboghazleh1, Shrouq Al-Sabaileh2, Mustafa Nadi3
1Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, Al-Salt 19117, Jordan.
Neurology International
|April 27, 2026
Summary
Severe traumatic brain injury (TBI) causes progressive coagulopathy and fibrinolysis, unlike mild TBI. Longitudinal monitoring of coagulation and fibrinolytic parameters is crucial for severe TBI management.
Area of Science:
- Neuroscience
- Hematology
- Trauma Research
Background:
- Traumatic brain injury (TBI) is linked to coagulation disorders.
- Coagulation and fibrinolytic parameters are vital in acute TBI management.
Purpose of the Study:
- To investigate coagulation and fibrinolytic changes over time after mild and severe TBI in a rat model.
- To determine if TBI-induced coagulopathy requires extended monitoring.
Main Methods:
- Induced mild and severe TBI in rats using a closed head injury model.
- Collected blood samples at multiple time points post-injury (1 day, 1, 2, 3, 4 weeks).
- Assessed prothrombin time (PT), partial thromboplastin time (PTT), D-dimer, and fibrinogen levels.
Main Results:
- Mild TBI showed minimal changes in hemostatic parameters.
- Severe TBI exhibited significant increases in PT and PTT within the first week.
- D-dimer levels significantly elevated at weeks 2 and 4 post-severe TBI.
- Fibrinogen levels increased at week 2 but remained within normal ranges after severe TBI.
Conclusions:
- Mild TBI is associated with stable hemostatic markers.
- Severe TBI triggers a progressive cascade from coagulation activation to secondary fibrinolysis.
- Coagulopathy in severe TBI necessitates prolonged monitoring beyond the acute phase.
