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Correlation Between Gut Microbiota and Plasma Metabolites in a Mouse Model for Post-Traumatic Stress Disorder
Daxue Zhou1, Youying Huang1, Fei Li1
1Biomedical Analysis Center, Army Medical University, Chongqing 400038, China.
Metabolites
|April 27, 2026
Summary
This study reveals gut microbiome and plasma metabolite changes in a mouse model of post-traumatic stress disorder (PTSD). Specific bacteria and metabolites were linked, offering insights into PTSD mechanisms.
Area of Science:
- Microbiology
- Metabolomics
- Neuroscience
Background:
- Post-traumatic stress disorder (PTSD) is linked to gut microbiota and plasma metabolites.
- The interplay between the gut microbiome and plasma metabolome in PTSD remains unclear.
- This research investigates these connections in a PTSD mouse model.
Purpose of the Study:
- To integrate gut microbiome and plasma metabolome data.
- To identify microbial-metabolite associations specific to PTSD.
- To elucidate potential mechanisms in PTSD etiology.
Main Methods:
- Induced PTSD in mice using single prolonged stress and electric foot shock.
- Analyzed gut microbiota composition via 16S rRNA gene sequencing.
- Performed plasma metabolomic profiling using UHPLC-MS/MS.
Main Results:
- PTSD mice showed anxiety, elevated IL-1β/TNF-α, and gut dysbiosis (depleted Muribaculaceae/Akkermansia, expanded Lachnospiraceae).
- Identified 24 dysregulated metabolites, including altered L-arginine, palmitic acid, oleic acid, and uridine.
- Found correlations between Muribaculaceae abundance and metabolites like L-arginine and L-glutamine.
Conclusions:
- This study explored the gut microbiota-plasma metabolite association network in a PTSD mouse model.
- Preliminary insights into microbe-metabolite interactions in PTSD were provided.
- Highlights potential targets for future PTSD research.
