Integrative Multi-Omics Analysis Reveals HNRNPLL as a Potential Biomarker Associated with Hepatocellular Carcinoma...

Area of Science:

• Oncology
• Molecular Biology
• Immunology

Background:

• Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) is an RNA-binding protein with known roles in splicing and immunity.
• Its specific function and impact in liver hepatocellular carcinoma (LIHC) are not well understood.

Purpose of the Study:

• To investigate the role of HNRNPLL in LIHC progression.
• To evaluate HNRNPLL as a prognostic biomarker and potential therapeutic target in LIHC.

Main Methods:

• Integrative multi-omics analyses (TCGA, GEO, Human Protein Atlas).
• Functional enrichment, immune-related analyses, and pathway exploration.
• In vitro (cell lines) and in vivo (xenograft mouse model) experimental validation.

Main Results:

• HNRNPLL is significantly upregulated in LIHC at transcriptomic and proteomic levels.
• High HNRNPLL expression correlates with advanced clinicopathological features and poor overall survival, identifying it as an independent prognostic factor.
• HNRNPLL knockdown inhibits LIHC cell proliferation, migration, invasion, and tumor growth in vivo.

Conclusions:

• HNRNPLL plays a significant role in LIHC progression, influencing cell cycle, EMT, and immune responses.
• HNRNPLL is a potential prognostic biomarker and therapeutic target for LIHC.
• Further mechanistic studies are warranted to fully elucidate HNRNPLL's functions in LIHC.