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Common Skin Diseases and Metabolic Syndrome: A Proinflammatory Chemokine Perspective

Mateusz Matwiejuk1, Hanna Myśliwiec1, Agnieszka Mikłosz2

  • 1Department of Dermatology and Venerology, Medical University of Bialystok, 15-540 Bialystok, Poland.

Metabolites
|April 27, 2026
PubMed

Insights

Chronic inflammatory skin diseases and metabolic syndrome share common inflammatory pathways. Pro-inflammatory chemokines play a key role in linking these conditions, impacting overall health.

Area of Science:

  • Dermatology
  • Immunology
  • Metabolic Disorders

Background:

  • Skin diseases often co-occur with metabolic syndrome, diabetes, and cardiovascular disease.
  • Shared inflammatory pathways, oxidative stress, and adipokine dysregulation link chronic skin inflammation and metabolic syndrome.

Purpose of the Study:

  • To review the association between chronic inflammatory skin diseases and metabolic syndrome.
  • To highlight the role of pro-inflammatory chemokines in these interconnected conditions.

Main Methods:

  • Narrative review of existing literature.
  • Focus on pathological and molecular connections.

Main Results:

  • Altered chemokine levels (e.g., CCL5, CXCL12, CCL2) contribute to inflammation in both skin diseases and metabolic syndrome.
  • Systemic inflammation is a common factor, though precise mechanisms require further elucidation.

Conclusions:

  • A robust association exists between various chronic inflammatory skin diseases and metabolic syndrome.
  • Pro-inflammatory chemokines are crucial mediators in the pathophysiology linking these conditions.
Keywords:
CCL2/MCP-1CCL5/RANTESCCL7/MCP-3CXCL1/GROaCXCL12/SDF-1aeotaxinmetabolic syndromepsoriasisskinskin diseases

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