Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

271
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
271
Cross-reactivity00:42

Cross-reactivity

28.7K
Overview
28.7K
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

2.0K
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
2.0K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

1.4K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analgesia in Tactical Combat Casualty Care (TCCC): TCCC Guideline Change 25-03.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals·2026
Same author

scSpatialSIM: a simulator of spatial single-cell molecular data.

SoftwareX·2026
Same author

Palliative rehabilitation is relationship-centered care.

Annals of palliative medicine·2026
Same author

Association Between Patient-Reported Engagement and Medical Record of Advance Care Planning Among Older Adults in the ED: A Cross Sectional Study.

The American journal of hospice & palliative care·2025
Same author

Interdisciplinary Training to Enhance Home Health Clinician Knowledge of Palliative Care: Findings from the PIVOT Pilot Study.

Journal of palliative medicine·2025
Same author

Role of rehabilitation in palliative care after the COVID-19 pandemic: a narrative review.

Annals of palliative medicine·2025
Same journal

Chemical, Biological, and Ecological Evidence for Aerobic Deoxynivalenol Detoxification in Agronomic Soil-Derived Bacterial Communities.

Toxins·2026
Same journal

Botulinum Toxin Treatment for Uncommon Phenotypes of Laryngeal Adductor Breathing Dystonia.

Toxins·2026
Same journal

Enhancing Neuronal Networks with <i>Rhinella schneideri</i> Skin Secretion Molecules: Implications for Neurodegenerative Disorders.

Toxins·2026
Same journal

Dangerous Measures: A Case Report and Review of Motoro Ray Envenomation.

Toxins·2026
Same journal

The Impact of OnabotulinumtoxinA on Oral Pain Medication Prescription Fills and Low-Value Care in Patients with Cervical Dystonia in the United States: A Retrospective Claims Analysis.

Toxins·2026
Same journal

Broad-Spectrum Antiviral and Antibacterial Activity of the Scorpion Venom Peptide HP1090.

Toxins·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production
05:27

Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production

Published on: October 6, 2023

4.7K

Lessons Learned from a Military-Biotechnology Partnership to Develop a Broad-Spectrum Small-Molecule Inhibitor for

Kendra L Lawrence1, Jeffery L Owen2, Lindsey S Garver1

  • 1Warfighter Protection & Acute Care, Operational Medical Systems, Defense Health Agency, Fort Detrick, MD 21702, USA.

Toxins
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

A novel oral snakebite treatment, varespladib, is being developed through a unique partnership between Ophirex and the US military. This collaboration aims to provide a shelf-stable, easy-to-administer therapy for snakebite envenoming, addressing critical pre-hospital care gaps.

Keywords:
phospholipase A2snake bitetranslation of innovationvarespladib

More Related Videos

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases
10:16

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Published on: August 16, 2024

2.2K
High Throughput Quantitative Expression Screening and Purification Applied to Recombinant Disulfide-rich Venom Proteins Produced in E. coli
12:16

High Throughput Quantitative Expression Screening and Purification Applied to Recombinant Disulfide-rich Venom Proteins Produced in E. coli

Published on: July 30, 2014

26.3K

Related Experiment Videos

Last Updated: Apr 28, 2026

Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production
05:27

Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production

Published on: October 6, 2023

4.7K
Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases
10:16

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Published on: August 16, 2024

2.2K
High Throughput Quantitative Expression Screening and Purification Applied to Recombinant Disulfide-rich Venom Proteins Produced in E. coli
12:16

High Throughput Quantitative Expression Screening and Purification Applied to Recombinant Disulfide-rich Venom Proteins Produced in E. coli

Published on: July 30, 2014

26.3K

Area of Science:

  • Pharmacology
  • Toxicology
  • Drug Development

Background:

  • Snakebite envenoming results in high mortality, with most deaths occurring before medical care.
  • Current antivenom treatments face limitations in availability, administration, and regional specificity.
  • There is a critical need for accessible, pre-hospital snakebite therapies.

Purpose of the Study:

  • To describe the strategic partnership between Ophirex and the US military for developing an oral snakebite treatment.
  • To highlight the convergence of military operational needs and global public health requirements for snakebite therapy.
  • To detail the integrated approach to drug development, from concept to advanced stages.

Main Methods:

  • Collaboration between a pharmaceutical company (Ophirex) and a government entity (US military).
  • Development of varespladib, an oral secretory phospholipase A2 (sPLA2) inhibitor.
  • Integrated program management encompassing operational requirements, regulatory planning, and risk mitigation.
  • Advancement of manufacturing, nonclinical, and clinical development.

Main Results:

  • A shared requirement for a shelf-stable, easy-to-administer, snake-species-agnostic therapy was identified.
  • The partnership successfully navigated complex drug development challenges.
  • Progress was made in manufacturing, nonclinical, and clinical development for varespladib.

Conclusions:

  • Structured partnerships can accelerate innovation in challenging environments.
  • Military operational needs can align with global public health goals for medical countermeasures.
  • The development of varespladib exemplifies a successful translation of research into a potentially life-saving therapy.