Related Experiment Video
Updated: Apr 28, 2026

06:07
Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
Published on: March 28, 2025
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Testing the mettle of RNA methylation in T cell exhaustion
Cansu Yerinde1,2,3, Debattama Rai Sen1,2,3
1Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
The Journal of Experimental Medicine
|April 27, 2026
Abstract
None:
Song et al. (https://doi.org/10.1084/jem.20250424) identify Mettl8 as a regulator of progenitor exhausted CD8+ T cells, stabilizing Tcf7 transcripts and shaping chromatin programs. Mettl8 loss drives effector differentiation and improves tumor control, underscoring RNA methylation as a key layer of T cell fate regulation.
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