Related Experiment Video For Digital single-operator cholangioscopy (D-SOC)
Updated: Jul 6, 2026
A Novel Dual-Modal Deep Learning Approach for Real-Time Removal of Hepatic Fluorescence in Indocyanine Green-Guided Laparoscopic Cholecystectomy
Published on: April 17, 2026
Diagnostic Utility of Digital Single-Operator Cholangioscopy for Risk-Enriched Detection and Surveillance of
Il Sang Shin1, Jong Ho Moon2,3, Yun Nah Lee1
1Digestive Disease Center, Department of Internal Medicine, SoonChunHyang University College of Medicine, Bucheon, Korea.
Background And Aim:
Detection of intraductal neoplasms of the bile duct (IN-Bs) remains suboptimal despite various diagnostic modalities. We evaluated the efficacy of digital single-operator cholangioscopy (D-SOC) for screening and surveillance of IN-Bs in patients with bile duct dilatation after stone removal.
Methods:
In a prospective cohort of 181 patients with post-stone removal common bile duct dilatation (> 10 mm), screening D-SOC was followed by two rounds of surveillance at 1-year intervals. Outcomes included cumulative incidence of IN-Bs, technical success of D-SOC and D-SOC-guided biopsy, and number needed to screen (NNS) to identify a neoplastic lesion at each round.
Results:
Technical success of D-SOC was achieved in all patients. Among 181 patients who underwent D-SOC, nine were diagnosed with IN-Bs: cholangiocarcinoma (CCA) (n = 3), intraductal papillary neoplasms of the bile duct (n = 5), and adenoma with dysplasia (n = 1). Curative resection was performed in two patients with CCA. The cumulative incidence of IN-Bs was 6.3% (95% confidence interval, 2.4-10.7%). The NNS values to detect one neoplastic lesion were 29.4, 21.8, and 9.7 at initial screening and 1- and 2-year surveillance.
Conclusion:
D-SOC can be useful for risk-enriched detection and surveillance of IN-Bs in patients with post-stone-removal biliary dilatation, warranting further evaluation in those with additional CCA risk factors (clinical trial registration number: NCT05600803).
