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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Bone transport accelerates diabetic foot ulcer healing via TGF-β1-mediated angiogenic and osteo-immune coupling

Yan Chen1,2, Xiajie Huang3,4, Chaoquan Yang5

  • 1Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China. cy003@connect.hku.hk.

Journal of Molecular Histology
|April 27, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
AngiogenesisBone transportDiabetic foot ulcerImmunomodulationTGF‑β1 signalingWound healing

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Diabetic Foot Ulcer01:31

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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