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Ups and downs in the experimental treatment of murine typhoid fever using gentamicin combined with caffeine

Esther de Souza Silva1, Roseane Thays Dos Santos Rocha1, Joyce Nayara Gomes da Silva1

  • 1Department of Biology, Federal Rural University of Pernambuco, Recife, PE, Brazil.

Brazilian Journal of Microbiology : [Publication of the Brazilian Society for Microbiology]
|April 27, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Salmonella typhimuriumImmunomodulationTherapeutic adjuvant

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Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
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