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Targeted Radiation, Unintended Evolution

Katharina Lueckerath1, Boris Hadaschik2, Ken Herrmann1

  • 1Department of Nuclear Medicine, University of Duisburg-Essen, DKTK-Partner Site University Hospital Essen, Essen, Germany.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 27, 2026
PubMed
Summary

Radioligand therapy can cause changes in blood cell development. This study reveals that [177Lu]Lu-PSMA treatment leads to specific genetic mutations in blood cells, suggesting a selection process rather than damage.

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