Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

788
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
788
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

595
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
595
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

750
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
750
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

942
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
942
Pulse rhythm01:30

Pulse rhythm

1.7K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.7K
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

1.7K
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomonitoring of nutritional and toxic elements in raw and cooked rice in the Health Effects of Arsenic Longitudinal Study, Bangladesh.

Ecotoxicology and environmental safety·2026
Same author

Influenza Antiviral Prescriptions in the US Inpatient and Outpatient Settings During the 2015-2022 Influenza Seasons.

Influenza and other respiratory viruses·2026
Same author

PERsonalised Medicine for Intensification of Treatment (PERMIT) in type 2 diabetes mellitus: a target trial emulation from routine data.

Health technology assessment (Winchester, England)·2026
Same author

Interplay Between the Gut-Microbiota-Brain Axis and the Immune System in Viral Neuroinvasion and CNS Pathogenesis.

Comprehensive Physiology·2026
Same author

From sensing to shaping: microglial responses in the pathogenesis of viral encephalitis.

Current opinion in immunology·2026
Same author

Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial.

JAMA cardiology·2026
Same journal

Education Leadership in Accreditation Reform-Reply.

JAMA·2026
Same journal

Complexity of Diagnosing Volume Overload.

JAMA·2026
Same journal

Incorrect Data in Rational Clinical Examination Article.

JAMA·2026
Same journal

Education Leadership in Accreditation Reform.

JAMA·2026
Same journal

Complexity of Diagnosing Volume Overload-Reply.

JAMA·2026
Same journal

Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection.

JAMA·2026
See all related articles

Related Experiment Video

Updated: Apr 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.2K

Cardiac Resynchronization Therapy: A Review.

Caique M Ternes1,2,3, Jitae A Kim4, Anirban Basu5

  • 1Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas.

JAMA
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy improves heart failure outcomes. Conduction system pacing may offer advantages over biventricular pacing in certain patients, reducing hospitalizations and improving ejection fraction.

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

2.3K
Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

28.4K

Related Experiment Videos

Last Updated: Apr 29, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.2K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

2.3K
Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

28.4K

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Heart failure (HF) affects over 64 million globally, with high mortality.
  • Cardiac dyssynchrony, often from left bundle-branch block, worsens HF in 20-30% of patients with reduced ejection fraction.
  • Current guidelines recommend cardiac resynchronization therapy (CRT) for symptomatic HF patients with LVEF ≤35% and LBBB.

Purpose of the Study:

  • To evaluate the effectiveness of cardiac resynchronization therapy (CRT) in heart failure (HF) patients.
  • To compare biventricular pacing (BVP) and conduction system pacing (CSP) for CRT.
  • To assess the impact of pacing strategies on mortality, hospitalizations, and left ventricular function.

Main Methods:

  • Meta-analysis of 5 randomized trials (N=3872) comparing BVP to medical therapy/ICD.
  • Meta-analysis of 7 trials (N=408) comparing CSP to BVP in HF patients.
  • Observational study (N=1778) comparing CSP to BVP in CRT patients.
  • Trial (N=249) comparing CSP to RV pacing for bradycardia.

Main Results:

  • Biventricular pacing (BVP) reduced all-cause mortality compared to medical therapy or ICD (13.7% vs 20.8%).
  • Conduction system pacing (CSP) improved LVEF compared to BVP (mean difference 2.06%, P=.03).
  • CSP was associated with lower HF hospitalization rates than BVP (12% vs 19%) and reduced pacing-induced cardiomyopathy compared to RV pacing (6% vs 15%).

Conclusions:

  • Cardiac resynchronization therapy is recommended for specific HF patients to improve outcomes.
  • Conduction system pacing demonstrates potential benefits, including improved LVEF and reduced hospitalizations, compared to biventricular pacing.
  • CSP may be a preferable alternative to RV pacing in certain patients, mitigating risks of pacing-induced cardiomyopathy.