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Electroacupuncture-induced Changes in Motor Protein Pathways in Postpartum Stress Urinary Incontinence.

Xiaoyu Jiang1, Huiling Liang2, Weiwei Sheng2

  • 1The Second Clinical College, Guangzhou University of Chinese Medicine; Guangzhou Nansha District Maternal and Child Health Hospital; ivyjiang123@163.com.

Journal of Visualized Experiments : Jove
|April 27, 2026
PubMed
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Electroacupuncture (EA) effectively treats postpartum stress urinary incontinence (SUI) in rats by improving bladder function and pelvic floor muscle structure. This therapy modulates motor protein pathways, offering new insights for SUI treatment.

Area of Science:

  • Urology
  • Integrative Medicine
  • Molecular Biology

Background:

  • Postpartum stress urinary incontinence (SUI) severely affects women's quality of life.
  • The molecular mechanisms of SUI treatments are not fully understood.

Purpose of the Study:

  • Investigate the therapeutic effects of electroacupuncture (EA) on SUI.
  • Elucidate the molecular pathways targeted by EA in a rat SUI model.

Main Methods:

  • Established SUI rat model using vaginal balloon dilation (VBD).
  • Assessed functional recovery via urodynamic testing (leak point pressure, maximum bladder capacity).
  • Performed histopathological analysis (H&E, Masson's trichrome) and quantitative proteomics.

Main Results:

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  • EA significantly improved leak point pressure and maximum bladder capacity.
  • EA reduced collagen deposition by 42.3% and suppressed inflammation.
  • Proteomics identified motor protein pathways (e.g., MYL1, TNNI2) as key targets modulated by EA.

Conclusions:

  • EA alleviates SUI symptoms by enhancing pelvic floor muscle contractility and remodeling.
  • EA offers a promising therapeutic strategy for SUI by targeting specific motor proteins.