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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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Published on: October 7, 2025

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Uses of miRNAs in Pediatric Diseases

Harun Bayrak1, Harun Yıldız2, Parisa Sharafi3

  • 1Department of Molecular Medicine, TOBB University of Economics and Technology Graduate School of Health Sciences, Ankara, Türkiye.

Turkish Archives of Pediatrics
|April 27, 2026
PubMed
Abstract

Insights

MicroRNAs (miRNAs) regulate gene expression and are vital for biological functions. This review highlights their potential as biomarkers and therapeutics for pediatric diseases, emphasizing noninvasive diagnostic methods.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating protein-coding gene expression.
  • They are crucial in cellular processes like proliferation, differentiation, and development.
  • miRNAs function by binding to target mRNA in the cytoplasm, inhibiting translation.

Purpose of the Study:

  • To comprehensively examine miRNA research in the context of pediatric diseases.
  • To emphasize the potential of miRNAs as biomarkers for diagnosing pediatric diseases.
  • To highlight miRNAs as alternative therapeutic agents for pediatric conditions.

Main Methods:

  • Literature review of current miRNA research.
  • Analysis of miRNA biogenesis and function.
  • Exploration of miRNA applications in pediatric disease diagnosis and therapy.

Main Results:

  • miRNAs play a significant role in regulating gene expression and biological functions.
  • miRNAs show promise as diagnostic biomarkers for various diseases.
  • miRNAs offer potential as novel therapeutic strategies.

Conclusions:

  • miRNAs are critical regulators of gene expression with broad biological roles.
  • Further research into miRNAs can lead to improved diagnostic tools and treatments for pediatric diseases.
  • Raising awareness of miRNA potential is key for advancing pediatric healthcare.
Keywords:
BiomarkerchildrenmicroRNAnon-coding RNAspediatrics

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