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Updated: Apr 29, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
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A Structured Approach to Extubation in Mechanically Ventilated Rats

Published on: July 18, 2025

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Clinical Characteristics of Extubation Failure in Critically Ill Children in Pediatric Intensive Care Unit

Irene Yuniar1, Daendy Nova Setia1, Devina June1

  • 1Department of Child Health, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia.

Turkish Archives of Pediatrics
|April 27, 2026
PubMed

Insights

Extubation failure in pediatric intensive care unit (PICU) patients occurred in 25.9%, particularly in younger children and those with pneumonia or prolonged mechanical ventilation. Identifying these risk factors is crucial for improving patient outcomes.

Area of Science:

  • Pediatric critical care medicine
  • Respiratory physiology
  • Mechanical ventilation

Background:

  • Mechanical ventilation is a cornerstone of pediatric intensive care unit (PICU) management.
  • Predicting successful extubation in pediatric patients is clinically challenging.
  • Extubation failure is linked to adverse outcomes, including increased mortality and prolonged hospital stays.

Purpose of the Study:

  • To identify clinical characteristics associated with extubation failure in pediatric patients.
  • To understand the factors contributing to unsuccessful weaning from mechanical ventilation.

Main Methods:

  • Observational, cross-sectional study design.
  • Inclusion of pediatric patients (1 month to 18 years) on mechanical ventilation.
  • Data collection on patient demographics, intubation indications, and ventilation duration.

Main Results:

  • Extubation failure was observed in 25.9% of 112 pediatric patients.
  • Younger age (under 1 year), pneumonia, and longer duration of mechanical ventilation were significant predictors of failure.
  • Surgical cases constituted the majority (61.6%) of intubation indications.

Conclusions:

  • A significant proportion of pediatric patients in the PICU experience extubation failure.
  • Medical indications for intubation and extended mechanical ventilation duration are associated with increased extubation failure risk.
Abstract

Keywords:
Extubation failurePICUmechanical ventilatorpediatrics

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