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Impact of a Multidisciplinary Algorithm on Early Complications After Hip Fracture Surgery: A Retrospective
Michele Carella1,2, Florian Beck1,3, Ambre Tanke1
1From the Department of Anesthesia and Intensive Care Medicine, Liege University Hospital, Liege, Belgium.
Anesthesia and Analgesia
|April 27, 2026
Summary
The Advise, Surgery, Analgesia, Pharmacology (ASAP) bundle significantly reduced early postoperative complications in elderly hip fracture patients. Early surgery and supra-inguinal fascia iliaca blocks were key factors in this improvement.
Area of Science:
- Geriatric Medicine
- Orthopedic Surgery
- Anesthesiology
- Public Health
Background:
- Hip fractures in the elderly are associated with high morbidity.
- Current management often focuses on isolated perioperative interventions.
- A coordinated multidisciplinary approach may offer superior outcomes.
Purpose of the Study:
- To evaluate the effectiveness of the Advise, Surgery, Analgesia, Pharmacology (ASAP) bundle in reducing early postoperative complications (EPOCs) within 7 days following hip fracture surgery.
- To assess the impact of a comprehensive perioperative algorithm on patient outcomes.
Main Methods:
- Retrospective, single-center interrupted time-series cohort study (January 2017-December 2022).
- Comparison of EPOC rates (Clavien-Dindo grades 1-4 and 2-4) between pre-ASAP and post-ASAP implementation periods.
- Interrupted time-series analysis, Kaplan-Meier curves, and Cox proportional hazards models were used.
Main Results:
- The ASAP bundle implementation led to an immediate and sustained reduction in all EPOCs (P = .032) and major EPOCs (P < .001).
- Post-ASAP, there was a significantly lower cumulative incidence of both all and major complications.
- The hazard for all EPOCs was reduced by 42% (HR, 0.58) and for major EPOCs by 40% (HR, 0.60).
- Early surgery and supra-inguinal fascia iliaca block (SFIB) independently predicted fewer complications.
Conclusions:
- The ASAP bundle is an effective multimodal strategy for reducing early postoperative complications in elderly hip fracture patients.
- Early surgical intervention and SFIB are critical components contributing to improved outcomes.
- This study supports the broader adoption of coordinated perioperative care algorithms for elderly patients with hip fractures.

