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Published on: August 13, 2019
Lateral Ridge Augmentation Using Low-dosage Bone Morphogenetic Protein-2 Functionalised Calcium Phosphate Cement
Lingfei Wei1, Yuanyuan Sun2, Yiqun Wu3
1Department of Oral Implantology, The Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai, China; Department of Second Dental Center, Shanghai Ninth People's Hospital, School of Medicine; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam and University of Amsterdam, Amsterdam, the Netherlands.
Low-dosage Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2) incorporated with calcium phosphate cement (CPC) significantly enhanced bone regeneration and ridge contour maintenance. This biomimetic coating method shows promise for dental implant procedures.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Dental Implantology
Background:
- Alveolar bone defects pose challenges for dental implant success.
- Enhancing bone regeneration and osseointegration is crucial for stable implant placement.
- Novel biomaterials are needed to improve outcomes in lateral ridge augmentation.
Purpose of the Study:
- To evaluate bone regeneration and osseointegration using low-dose ErhBMP-2 incorporated with CPC.
- To assess the efficacy of a biomimetic coating method for simultaneous lateral ridge augmentation and implant placement.
Main Methods:
- Chronic horizontal alveolar bone defects were created in canine mandibles.
- Defects were treated with autologous bone, CPC, high-dose ErhBMP-2 adsorbed CPC, or low-dose ErhBMP-2 incorporated CPC.
- Lateral ridge augmentation and implant placement were performed, followed by micro-CT and histological analysis at 3 months.
Main Results:
- The ErhBMP-2 incorporated CPC group showed substantial mineralized tissue covering the implant surface.
- Significantly greater trabecular thickness was observed in the ErhBMP-2 incorporated CPC group compared to CPC and autologous bone groups.
- Enhanced bone marrow formation and horizontal augmentation were confirmed histologically in the ErhBMP-2 incorporated CPC group.
Conclusions:
- Low-dose ErhBMP-2 incorporated into CPC significantly enhances peri-implant bone regeneration compared to CPC alone.
- This approach offers a predictable and effective method for simultaneous lateral ridge augmentation and implant placement, improving bone regeneration and ridge contour maintenance.
