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Updated: Apr 29, 2026

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
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Statin-Associated Hepatotoxicity Linked to CASP8 Polymorphisms: Mechanistic Insights from Proteomic Analysis

Da Hoon Lee1, Yoon-A Park1, Seo-A Choi1

  • 1College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea.

Yonsei Medical Journal
|April 27, 2026
PubMed
Summary

Certain caspase-8 (CASP8) gene variations increase the risk of liver damage in individuals taking statins. This finding may help predict and prevent statin-associated hepatotoxicity.

Keywords:
Hydroxymethylglutaryl-CoA reductase inhibitorscaspase 8drug-induced liver injurypolymorphismproteomics

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