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Updated: Apr 29, 2026

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
The history and function of a circular RNA
Cledi A Cerda-Jara1, Flavia Scoyni1, Grygoriy Zolotarov2,3
1Laboratory for Systems Biology of Gene Regulatory Elements, Berlin Institute for Medical Systems Biology Max Delbrück Centre for Molecular Medicine Hannoversche Str. 28 10115, Berlin, Germany.
Abstract:
Cdr1as/ciRS-7 is a circular RNA conserved in mammals and highly expressed in brain. It features a large number of microRNA target sites bound in vivo by miR-7/miR-671. Cdr1as regulates synaptic activity under stress in a temporal, spatial, and neuron-specific manner. We review genetic, molecular, evolutionary, and physiological data to discuss how Cdr1as and its interactors form a functionally important network of non-coding RNAs that regulates neuronal adaptability. We provide a framework to explore potential roles of other non-coding RNA networks on brain function and their diagnostic and therapeutic potential.
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