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Integrating bulk and single-cell RNA sequencing identifies and validates lactylation-related signatures in diabetic

Xiao Peng1, Wenqiang Wang1, Xinyu Nie2

  • 1The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous, China.

Scientific Reports
|April 27, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Diabetic foot ulcerfibroblast heterogeneityimmune microenvironmentlactylationmachine learningmetabolic reprogrammingsingle-cell RNA sequencing

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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