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Published on: May 22, 2018
Electrophysiologic evaluation of elderly patients with sinus bradycardia: a long-term follow-up study
Insights
Persistent sinus bradycardia survival rates are comparable to the general population. Abnormal corrected sinus-node recovery time accurately predicts serious sinus node disease, aiding pacemaker selection, especially for syncope patients.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- Persistent sinus bradycardia is a common cardiac arrhythmia.
- Evaluating its long-term prognosis and diagnostic tools is crucial.
Purpose of the Study:
- To assess the long-term survival of patients with persistent sinus bradycardia.
- To evaluate the diagnostic accuracy of corrected sinus-node recovery time (CNRT) in predicting serious sinus node disease.
Main Methods:
- Prospective electrophysiological evaluation and follow-up of 103 patients with persistent sinus bradycardia.
- Analysis of corrected sinus-node recovery time (CNRT) and its correlation with clinical outcomes and symptoms.
Main Results:
- The 5-year survival rate was 74.8%, similar to the general population.
- Abnormal CNRT predicted serious sinus node disease with 90% accuracy overall and 100% in syncope patients.
- CNRT sensitivity was 66%.
Conclusions:
- Sinus bradycardia patients have a comparable survival rate to the general population.
- Abnormal CNRT is a specific and predictive index for serious sinus node disease.
- CNRT is a valuable tool for selecting patients for pacemaker therapy, particularly those with syncope.
Abstract:
One hundred three patients with persistent sinus bradycardia were evaluated electrophysiologically and followed prospectively for a mean of 4.6 years. The 5-year survival rate was 74.8%, not significantly different from the 72% rate in the general population with similar age and sex distribution. Forty-one patients had abnormal corrected sinus-node recovery time. Overall accuracy of abnormal corrected sinus-node recovery time in predicting serious sinus node disease in symptomatic and asymptomatic patients was 90% (37 of 41 patients) and 100% in patients with syncope (18 of 18 patients). The sensitivity of the test was 66%. Abnormal corrected sinus-node recovery time in patients with sinus bradycardia appears to be a valuable specific, predictive index of serious sinus node disease and therefore a useful test in selecting patients for pacemaker therapy, especially if symptoms such as dizziness or syncope are present.
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