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Updated: Apr 29, 2026

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
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Effectiveness of Riboflavin in Inherited Metabolic Diseases: A Systematic Review.

Bregje Jaeger1, Nina N Stolwijk2,3, Femke Aaldering4

  • 1Department of Child Neurology, Emma Children's Hospital, Amsterdam UMC, Amsterdam, the Netherlands.

Journal of Inherited Metabolic Disease
|April 28, 2026
PubMed
Summary

Riboflavin (RF, vitamin B2) is effective for treating MADD type 3, RTD 2,3, ACAD 9, and FAD transporter deficiency in inherited metabolic diseases (IMDs). While safe and beneficial for these conditions, its efficacy remains uncertain for many other IMDs, warranting further investigation.

Keywords:
inherited metabolic diseasemultiple acyl‐CoA dehydrogenase deficiencyriboflavinriboflavin transporter deficiencysystematic reviewvitamin B2

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