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A Case of Voltage-Gated Calcium Channel and TG6 Antibody-Positive Cerebellar Ataxia

Alberto Cifelli1, Zain Butt2, Eva Cifelli3

  • 1Department of Neurology, Queen's Hospital, London, UK, queens-hospital.com.

Case Reports in Neurological Medicine
|April 28, 2026
PubMed

We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage-gated calcium channel antibodies (VGCCAs) and was started on immunosuppressive and immunomodulating therapy with no further worsening of her neurological status. Subsequent testing revealed that she was also TG6 antibody-positive, and a gluten-free diet was added to her management, following which improvement in cerebellar N-acetyl-aspartate (NAA) concentration (an index of neuronal health/integrity) was noted on magnetic resonance spectroscopy (MRS), while her clinical picture remained static.

Keywords:
Scale for the Assessment and Rating of AtaxiaTG6 autoantibodyantivoltage-gated calcium channel autoantibodycerebellar ataxiamagnetic resonance imagingmagnetic resonance spectroscopy

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