Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

161
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
161
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

226
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
226
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

159
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
159
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

231
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
231
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

310
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
310
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

163
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
163

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioorthogonal Click Chemistry Engineered Bioinks for 3D Bioprinting in Osteochondral Regeneration and Osteoarthritis Therapy: A Translational Review.

ACS applied bio materials·2026
Same author

Nature's blueprint: Exopolysaccharides linking microbiome dynamics to advanced bone tissue engineering.

Carbohydrate polymers·2026
Same author

Progressive Hydrogel Applications in Diabetic Foot Ulcer Management: Phase-Dependent Healing Strategies.

Polymers·2025
Same author

Nature-Inspired Bioelectric Stimuli-Based Electroactive Polymeric Therapeutics Technology for Osteoarthritis Treatment─A Review.

ACS biomaterials science & engineering·2025
Same author

Biofunctional supramolecular injectable hydrogel with spongy-like metal-organic coordination for effective repair of critical-sized calvarial defects.

Asian journal of pharmaceutical sciences·2025
Same author

Balloon expandable coronary stent materials: a systematic review focused on clinical success.

In vitro models·2025

Related Experiment Video

Updated: Apr 29, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

4.0K

Quercetin-Based Advanced Delivery Systems - From Multimodal Nano-theranostics to Microneedles: a Recent Update on

Maya Beena1,2, Anjaneyulu Udduttula2, Arunkumar Palaniappan3

  • 1School of Bioscience and Technology (SBST), Vellore Institute of Technology, Vellore, Tamil Nadu, India.

International Journal of Nanomedicine
|April 28, 2026
PubMed
Summary

Quercetin shows promise for treating diseases, but faces delivery challenges. New quercetin-based theranostic platforms offer improved targeting and efficacy for advanced nanomedicine applications.

Keywords:
3D bioprintedmicroneedlemultifunctionalpharmaceuticalsquercetintheranostics

More Related Videos

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

469
Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction
06:25

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Published on: December 30, 2025

326

Related Experiment Videos

Last Updated: Apr 29, 2026

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

4.0K
Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

469
Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction
06:25

Fabrication of Dissolvable Microneedle Patches Loaded with α-Lactalbumin Nanomicelles for Transdermal Capsaicin Delivery and Adipose Tissue Reduction

Published on: December 30, 2025

326

Area of Science:

  • * Biomaterials Science
  • * Nanotechnology
  • * Pharmacology

Background:

  • * Quercetin, a natural flavonoid, exhibits potent anticancer, antimicrobial, anti-inflammatory, and antioxidant properties, making it a promising therapeutic agent.
  • * Clinical applications of quercetin are hindered by poor solubility, low bioavailability, rapid metabolism, and challenges in targeted delivery.
  • * Existing theranostic systems using nanoparticles face limitations in biocompatibility, cost, biodegradability, and targeting precision.

Purpose of the Study:

  • * To systematically review the design strategies, biomedical applications, and potential of quercetin-based multifunctional theranostic systems.
  • * To highlight quercetin platforms as a novel alternative to overcome limitations of traditional theranostics.
  • * To identify challenges and future directions for quercetin-based nano-theranostics.

Main Methods:

  • * Comprehensive literature review on quercetin formulations and theranostic systems.
  • * Analysis of innovative strategies including nanoencapsulation, polymeric carriers, and surface modification.
  • * Evaluation of traditional theranostic platforms and their limitations.

Main Results:

  • * Innovative formulation strategies significantly enhance quercetin's stability, bioavailability, and targeted delivery.
  • * Quercetin-based platforms are emerging as effective alternatives to traditional theranostics, addressing issues of biocompatibility and cost.
  • * Advancements in design strategies enable controlled and stimuli-responsive delivery of quercetin.

Conclusions:

  • * Quercetin-based theranostics represent a promising frontier in precision medicine, merging diagnostics and therapeutics.
  • * Further research is needed to address challenges in controlled delivery, in vivo validation, and scalability for clinical translation.
  • * Developing next-generation quercetin nano-theranostics holds significant potential for future therapeutic advancements.