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Updated: Apr 29, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
peri-Selective C-H activation-initiated spiroannulation leading to spiropolycyclic compounds with unique
Qianting Zhou1, Jiayi Zou1, Haiyun Xu2
1State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China. gongyijun@htu.cn.
Abstract:
Presented herein is a peri-selective C-H activation-initiated spiroannulation leading to an effective and concise construction of spirocyclic skeletons. With this reaction, benzo[de]isoquinoline spiroisoquinolinone and benzo[de]isoquinoline spironaphthalenone derivatives, otherwise difficult to obtain, were prepared with broad substrate scope and good functional group compatibility. In addition, the products thus obtained showed unique photophysical properties and strong anticancer activity, indicating their potential to be developed as anticancer lead compounds with self-tracking capability via fluorescence detection.
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