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  1. Home
  3. 3d-printed Functional Engineered Intestinal Models.
  1. Home
  3. 3d-printed Functional Engineered Intestinal Models.

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3D-printed functional engineered intestinal models.

Jin Xue1, Qiancheng Jiao1, Renjun Pei1

  • 1Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China. xyliu2016@sinano.ac.cn.

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|April 28, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

3D bioprinting advances are creating sophisticated intestinal models that mimic native tissue. These biomimetic models offer improved drug screening and disease modeling capabilities for preclinical research.

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Traditional 2D and static 3D intestinal models lack the complexity of native tissue, limiting their predictive power for drug responses and disease mechanisms.
  • The intestine is crucial for nutrient absorption, immune function, and maintaining barrier integrity, making accurate in vitro models essential for physiological studies.

Purpose of the Study:

  • To systematically review the latest advancements in 3D bioprinting for creating biomimetic intestinal models.
  • To explore the techniques, materials, and strategies used in constructing these complex models.
  • To discuss the applications, challenges, and future directions in the field.

Main Methods:

  • Review of current literature on 3D bioprinting techniques for intestinal tissue engineering.
  • Analysis of bioink formulations, cell sources, and structural fabrication strategies.
  • Exploration of integration with organ-on-a-chip systems and applications in drug screening and disease modeling.

    • Main Results:

    • 3D bioprinting enables the reconstruction of complex gut architectures with improved biomimicry, cellular diversity, and microenvironmental cues.
    • Novel bioinks and printing methods are key technological drivers in creating more physiologically relevant intestinal models.
    • These models show expanding applications in drug screening, studying intestinal development, diseases, and tissue repair.

    Conclusions:

    • 3D bioprinting is revolutionizing the development of in vitro intestinal models, enhancing their ability to replicate native tissue.
    • Significant progress has been made, but challenges in achieving full physiological maturity, scalability, standardization, and cost-effectiveness remain.
    • Future research should focus on enhancing model fidelity, enabling multi-organ integration, and improving translational potential for clinical applications.