Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation.

Nature communications·2026

Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026

Same author

Spatial Single-Cell Proteomics Reveals Molecular Trajectories Of Tangle-Bearing Neurons In Alzheimer's Disease.

bioRxiv : the preprint server for biology·2026

Same author

Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor.

Immunity·2026

Same author

Neuromodulation of a peripheral nerve using fully polymeric cuff electrodes: understanding predictability of selective stimulation.

Journal of neural engineering·2026

Same author

In vivo acoustoelectric neural recording in mice enabled by ultrasound-induced frequency mixing.

Communications engineering·2026

Same journal

Deep Learning Network-Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Autonomous High-Throughput Characterization of Liquid-Liquid Phase Behavior.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Laser Preset of MnO<sub>x</sub> Layer on High-Entropy Alloy Surface for Ampere-Level Ultra-Stable OER Performance.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

PDGFRα<sup>+</sup>/Integrin α2<sup>+</sup> Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano-Metabolic Symbiosis: E-Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Synergistic Ni Single Atoms/Nanoparticles on CeO<sub>2</sub> for High-Performance and Durable SOFC Hydrogen Electrodes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

A Review of Failure Modes and Safety Strategies of Lithium-Ion Batteries from Materials to Systems.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 29, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Temporal Interference Stimulation Enhances Neural Regeneration.

Sofia Peressott^1,2,3,4, Maria Garcia Garrido², Patrycja Dzialecka^2,3

¹Bioengineering Department, Imperial College London, South Kensington, London, UK.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|April 28, 2026

Summary

This summary is machine-generated.

Temporal interference (TI) stimulation, a non-invasive technique, enhances neural progenitor cell maturation and hippocampal neurogenesis. This method offers a novel approach for deep brain neural regeneration without drugs or genetic modification.

Keywords:

adult neurogenesis alzheimer's disease neural progenitor cells neural regeneration neuromodulation temporal interference stimulation

More Related Videos

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Related Experiment Videos

Last Updated: Apr 29, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury

Published on: February 23, 2015

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Area of Science:

Neuroscience
Regenerative Medicine
Biomedical Engineering

Background:

Neural regeneration therapies aim to treat neurodegeneration by enhancing neural progenitor cell (NPC) proliferation and maturation.
Current therapies have limited efficacy, and deep brain stimulation (DBS) is invasive.
Temporal interference (TI) stimulation offers a non-invasive, precise alternative for deep brain neuromodulation.

Purpose of the Study:

To validate TI stimulation as a strategy for augmenting neural regeneration in the central nervous system (CNS).
To investigate the effects of theta-band TI stimulation on neural progenitor cell maturation and neurogenesis.
To explore a non-pharmacological, non-genetic approach for deep brain regeneration.

Main Methods:

In vitro assessment of embryonic neural progenitor cell maturation under theta-band TI stimulation.
In vivo evaluation of hippocampal neurogenesis in a mouse model of Alzheimer's disease-like amyloidosis using theta-band TI stimulation targeting the hippocampus.
Utilizing multiple kHz-range electric fields for focal deep brain stimulation.

Main Results:

Theta-band TI stimulation significantly enhanced the maturation of embryonic neural progenitor cells in vitro.
Targeted theta-band TI stimulation promoted endogenous hippocampal neurogenesis in vivo in an Alzheimer's disease mouse model.
Demonstrated frequency-specific control over stem cell fate via electrical stimulation.

Conclusions:

TI stimulation, particularly at theta-band frequencies, is a promising non-invasive method for enhancing neural regeneration.
This approach offers a clinically relevant strategy for deep brain regeneration, avoiding pharmacological or genetic interventions.
The findings enable focal, non-invasive augmentation of deep-brain neural regeneration through electrical stimulation.