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Updated: Apr 30, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
Published on: August 8, 2025
Xanthonolignoids from Hypericum curvisepalum with quorum sensing inhibitory activity against Chromobacterium
Qiu-Ying He1,2, Sheng-Qiang Yang2, Yik-Ling Chew3
1Department of Emergency, Affliated Hospital of Youjiang Medical University for Nationalities, Baise533000, China.
Abstract:
Three undescribed xanthonolignoids (1-3), together with eight known analogs (4-11), were isolated from Hypericum curvisepalum. Their structures were elucidated by mass and NMR spectroscopic analyses. In bioassays against Chromobacterium violaceum ATCC 12472, compounds 1, 4, 6, 7 and 9 exhibited potential quorum sensing (QS) inhibitory activity at 250 μM, with violacein inhibition rates of 84.92%, 74.96%, 70.47%, 71.43% and 76.87%, respectively. Furthermore, the three new compounds dose-dependently inhibited biofilm formation and significantly suppressed both swimming and swarming motility of C. violaceum ATCC 12472.
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