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Updated: Apr 30, 2026
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
Published on: November 7, 2015
Tumor Cell Lines as a Biosensor Substrate for Pathological Aging and CNS Tumors
V V Kudelkina1,2, A M Kosyreva3,4, E A Miroshnichenko3,4
1Petrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia. verakudelkina8047@gmail.com.
Abstract:
Primary screening of the sera from aging Wistar rats and animals with high-grade gliomas was performed using the following cell lines: Gasser's node neuroma (NGUK, trigeminal schwannoma) and high-grade glioma 11-9-2. Targeted analysis of the transcripts of the marker genes S100b (involved in nervous system homeostasis and damage), Sox2 (stemness marker), and Mki67 (proliferation marker), along with mitotic cell counting revealed statistically significant differences in transcriptional activity between the groups. This initial assessment of the sensitivity of cell lines to sera from animals with CNS pathology indicates its potential for further detailed development as a biosensor test system.
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