Related Experiment Video
Updated: Apr 30, 2026
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Evaluation of White Blood Cell Ratios in Newly Diagnosed Multicentric Lymphoma in Dogs
Lora Koenhemsi1, Sinem Yaren Güzelbakan2, Askarbek Tulobaev3
1Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Background And Objective:
Lymphoma is one of the most common malignancies in dogs. In human medicine, complete blood count (CBC)-derived inflammatory ratios, such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR), have been investigated as potential biomarkers in cancer. However, studies evaluating these parameters in canine lymphoma are limited. This study aimed to compare NLR, MLR and PLR values between dogs diagnosed with lymphoma and healthy controls.
Methods:
A total of 26 dogs with lymphoma and 10 clinically healthy dogs were included. CBC parameters were analysed, and NLR, MLR and PLR were calculated.
Results:
NLR and PLR values were significantly higher in dogs with lymphoma compared to healthy dogs, whereas MLR decreased.
Conclusion:
These findings indicate that CBC-derived inflammatory ratios, particularly NLR and PLR, are elevated in dogs with lymphoma and may reflect tumour-associated systemic inflammation. Further studies are needed to evaluate their potential clinical utility.
More Related Videos
14:04Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
11:39Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019