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Home
Ct-based Opportunistic Screening For Adding Clinical Value: How I Do It.

Home
Ct-based Opportunistic Screening For Adding Clinical Value: How I Do It.

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CT-based Opportunistic Screening for Adding Clinical Value: How I Do It.

Perry J Pickhardt^1,2, Mathew H Lee¹, Joshua D Warner¹

¹Department of Radiology, University of Wisconsin School of Medicine & Public Health, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252.

|April 28, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Opportunistic CT screening using artificial intelligence (AI) can detect unsuspected conditions like osteoporosis and cardiovascular disease. Automated analysis of body CT scans offers personalized precision medicine and potential cost savings.

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Area of Science:

Radiology
Artificial Intelligence
Precision Medicine

Background:

Body CT scans contain valuable cardiometabolic information.
Manual measurements and subjective assessments hinder clinical implementation of opportunistic CT screening.
Emerging explainable AI algorithms offer automated solutions.

Purpose of the Study:

To outline current and emerging automated approaches for opportunistic CT screening.
To highlight the potential of AI in leveraging cardiometabolic information from CT scans.
To discuss the application of AI-driven CT screening in personalized medicine.

Main Methods:

Review of current "on the fly" CT measurement approaches.
Focus on emerging automated solutions using explainable AI.

Development of composite models combining multiple cardiometabolic CT biomarkers.

Main Results:

AI enables detection of unsuspected conditions (osteoporosis, cardiovascular disease, sarcopenia, hepatic steatosis).
Composite models can predict survival, assess biologic aging, frailty, and fracture risk.
Automated opportunistic screening offers value, cost savings, and personalized medicine.

Conclusions:

Explainable AI is poised to revolutionize opportunistic CT screening.
Automated analysis of CT scans can lead to early preventive interventions.
AI-driven opportunistic CT screening represents a new era of personalized precision medicine.