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Related Concept Videos

Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Liver Histology01:27

Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
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Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
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Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Major Organs of the Digestive System01:19

Major Organs of the Digestive System

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The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:
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Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model
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The Liver We Share.

Ryan P Wexler1

  • 1Boston University Chobanian & Avedisian School of Medicine, Boston, MA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 28, 2026
PubMed
Summary
This summary is machine-generated.

A medical student becomes a living liver donor for his wife battling metastatic pancreatic cancer. This profound experience reshapes his medical perspective amidst shared uncertainty.

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Area of Science:

  • Medicine
  • Oncology
  • Transplant Surgery

Background:

  • A medical student's initial exposure to hepatectomy procedures.
  • The critical need for liver donors in managing complex diseases.

Purpose of the Study:

  • To explore the multifaceted impact of living donation on a medical professional.
  • To examine the intersection of personal experience and medical practice in advanced cancer care.

Main Methods:

  • Case study detailing a personal journey involving living liver donation.
  • Qualitative reflection on the patient and physician roles.

Main Results:

  • A transformative understanding of patient vulnerability and medical ethics.
  • The emotional and psychological challenges faced by patients and families during cancer treatment.

Conclusions:

  • Living donation offers a unique perspective on surgical interventions and patient care.
  • The experience highlights the profound connection between medical knowledge and empathetic practice in oncology.