Trop2 immunoPET/CT in clinical practice: facts and challenges

Area of Science:

• Oncology
• Molecular Imaging
• Radiochemistry

Background:

• Trophoblast cell surface antigen 2 (Trop2) is a key antigen overexpressed in epithelial cancers, making it a significant target for diagnostics and therapeutics.
• Immuno-positron emission tomography/computed tomography (immunoPET/CT) leverages antibody specificity and PET/CT resolution for advanced cancer management.

Purpose of the Study:

• To review the development and applications of Trop2-targeted immunoPET/CT.
• To highlight its potential in cancer diagnosis, staging, and guiding Trop2-targeted therapies.
• To discuss challenges and future directions for integrating this technology into personalized medicine.

Main Methods:

• Review of literature on Trop2-targeted immunoPET/CT tracer design.
• Analysis of preclinical data and translational studies.
• Discussion of clinical applications and future prospects.

Main Results:

• Trop2-targeted immunoPET/CT enables noninvasive visualization of Trop2-expressing tumors.
• It aids in accurate cancer diagnosis, staging, restaging, and patient selection for therapy.
• The technique shows potential for monitoring treatment response and guiding Trop2-targeted therapies.

Conclusions:

• Trop2-targeted immunoPET/CT is a promising tool for precision oncology.
• Its integration with Trop2-targeted therapies can significantly improve clinical outcomes.
• Further development is needed to fully realize its potential in personalized cancer care.