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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Obesity and Pro-Inflammatory Cytokines: Gene Expression Patterns Within Cervical Cancer Progression.

Isui Abril García-Montoya1, Livier Picazo-Pérez2, Ana Lidia Arellano-Ortiz2

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|April 28, 2026
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Obesity exacerbates cervical cancer (CC) by increasing pro-inflammatory cytokines like TNF-α, IL-6, and IL-10, while suppressing IL-8 and VEGF. This suggests obesity promotes a pro-inflammatory environment contributing to CC development alongside HPV infection.

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Cervical cancercytokinesobesity

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Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Cervical cancer (CC) is a major global health issue, with rising obesity rates potentially influencing its pathogenesis.
  • Chronic inflammation, driven by cytokine dysregulation, is implicated in cancer development.
  • Understanding the interplay between obesity, inflammation, and CC is crucial for public health.

Purpose of the Study:

  • To investigate the gene expression of key inflammatory and angiogenic cytokines (TNF-α, IL-6, IL-8, IL-10, VEGF) in cervical lesions.
  • To analyze how gene expression differs across varying stages of cervical pathology and body mass index (BMI) categories.
  • To explore the role of obesity-associated inflammation in cervical cancer progression.

Main Methods:

  • Cervical tissue samples were collected from 81 women and categorized by diagnosis (NIL, LSIL, HSIL, CC) and BMI.
  • Gene expression levels of TNF-α, IL-6, IL-8, IL-10, and VEGF were quantified using Polymerase Chain Reaction (PCR).
  • The Relative Expression Index was normalized against the 18S housekeeping gene.

Main Results:

  • Overexpression of TNF-α, IL-6, and IL-10 correlated with increased cervical lesion severity.
  • IL-8 expression was suppressed as cervical pathology advanced.
  • In overweight and obese patients with HSIL and CC, a trend towards higher IL-6, IL-10, and TNF-α expression was observed, while IL-8 and VEGF were repressed.

Conclusions:

  • Obesity acts as a risk factor for cervical cancer development.
  • Obesity promotes a pro-inflammatory microenvironment that facilitates CC, particularly in conjunction with Human Papillomavirus (HPV) infection.
  • Targeting inflammatory pathways in obese individuals may offer novel strategies for CC prevention and treatment.