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Pain in Children With ADHD: Mechanisms, Clinical Presentation, and Implications for Assessment and Management
Maria Rosaria Muzio1, Alessandro Vittori2, Teresa Grimaldi Capitello3
1Division of Infantile Neuropsychiatry, UOMI-Maternal and Infant Health, ASL NA3 SUD Torre del Greco, Naples, Italy.
Insights
Children with attention-deficit/hyperactivity disorder (ADHD) may experience and express pain differently. Tailoring pain management to their neurodevelopmental profile is crucial for effective care.
Area of Science:
- Pediatric neurology
- Developmental psychology
- Pain research
Background:
- Pain assessment and management are challenging in children, especially those with neurodevelopmental disorders like attention-deficit/hyperactivity disorder (ADHD).
- ADHD involves alterations in attention, executive function, and emotional regulation, domains critical to pain perception and expression.
- Children with ADHD may exhibit atypical pain experiences, behaviors, and face significant hurdles in pain management.
Purpose of the Study:
- To critically examine the neurobiological, psychological, and clinical interactions between ADHD and pain in children.
- To synthesize fragmented literature on pediatric ADHD and pain across various study types.
- To propose future directions for child-centered pain care.
Main Methods:
- This study employed a narrative review approach.
- It critically examined existing literature on the interplay between ADHD and pain in pediatric populations.
- The review synthesized findings from experimental, clinical, and behavioral studies.
Main Results:
- Proposed mechanisms linking ADHD to altered pain processing were discussed.
- Evidence on pain perception and expression in children with ADHD was summarized.
- Clinically relevant pain conditions and assessment/management challenges were explored.
Conclusions:
- ADHD should be viewed as a modifier of pain experience and a potential contributor to chronification, not just a comorbidity.
- Adapting pain assessment and management strategies to the specific neurodevelopmental profile of pediatric patients is essential.
- Future research should focus on function- and child-centered pain care.
Background/Aim:
Pain assessment and management in children remain challenging, particularly in those with neurodevelopmental disorders. Attention-deficit/hyperactivity disorder (ADHD) is characterized by alterations in attention, executive function, emotional regulation, and reward processing. These domains are also critically involved in pain perception and expression. Emerging evidence suggests that children with ADHD may experience pain differently, display atypical pain behaviors, and face substantial challenges in pain assessment and treatment. However, the literature on pediatric ADHD and pain is fragmented across experimental, clinical, and behavioral studies.
Materials And Methods:
This narrative review critically examines the neurobiological, psychological, and clinical interactions between ADHD and pain in children.
Results:
We discuss proposed mechanisms linking ADHD to altered pain processing, summarize evidence on pain perception and expression, explore common pain conditions where this interaction is clinically relevant, and analyze challenges in pain assessment and management. Finally, we identify knowledge gaps and propose future directions toward function- and child-centered pain care.
Conclusion:
By considering ADHD as a modifier of pain experience and a potential contributor to pain chronification rather than a mere comorbidity, this review highlights the importance of adapting pain assessment and management strategies to the specific neurodevelopmental profile of pediatric patients.
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