Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.5K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.5K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

2.0K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
2.0K
Association Areas of the Cortex01:21

Association Areas of the Cortex

10.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
10.2K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Organization of the Brain01:30

Organization of the Brain

3.8K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.8K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

8.8K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Long-Term Memory Engrams From Development to Adulthood.

Hippocampus·2025
Same author

Prefrontal cortex development and its implications in mental illness.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2025
Same author

Measurement of Human Body Segment Properties Using Low-Cost RGB-D Cameras.

Sensors (Basel, Switzerland)·2025
Same author

A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.

bioRxiv : the preprint server for biology·2025
Same author

Microglia regulate nucleus accumbens synaptic development and circuit function underlying threat avoidance behaviors.

Research square·2025

Related Experiment Video

Updated: Apr 30, 2026

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

8.3K

The prefrontal cortex controls memory organization in the hippocampus.

André F de Sousa1, Zachary E Zeidler2, Daniel G Almeida-Filho3,4

  • 1Departments of Neurobiology, Psychiatry & Biobehavioral Sciences, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, UCLA, Los Angeles, CA, USA. andrefil.sousa@gmail.com.

Nature Neuroscience
|April 28, 2026
PubMed
Summary

The ventromedial prefrontal cortex regulates memory integration in the hippocampus by assessing contextual similarities between experiences. This brain region controls how new and old memories are organized, preventing improper linking.

More Related Videos

Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

19.9K
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

18.4K

Related Experiment Videos

Last Updated: Apr 30, 2026

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

8.3K
Horizontal Hippocampal Slices of the Mouse Brain
08:59

Horizontal Hippocampal Slices of the Mouse Brain

Published on: September 22, 2020

19.9K
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
09:34

Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice

Published on: June 19, 2019

18.4K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • Memory integration facilitates learning by organizing prior knowledge with new experiences.
  • Regulation is crucial to prevent the inappropriate linking of unrelated memories.
  • The neural mechanisms controlling memory integration remain largely unknown.

Purpose of the Study:

  • To investigate the biological mechanisms controlling memory integration.
  • To identify the brain regions involved in regulating the integration of memories.
  • To elucidate how contextual similarities influence memory organization.

Main Methods:

  • Utilized advanced in vivo imaging techniques in mice.
  • Employed chemogenetic and optogenetic methods for precise neural manipulation.
  • Analyzed neural activity, ensemble overlap, and cellular responses in specific brain regions.

Main Results:

  • The ventromedial prefrontal cortex (vmPFC) is recruited over time to control hippocampal memory integration.
  • vmPFC exerts control via projections to the medial entorhinal cortex, modulating its activity.
  • This pathway influences ensemble overlap in the dorsal hippocampus, neurogliaform cell activity in CA1, and memory allocation.

Conclusions:

  • The vmPFC plays a critical role in regulating memory integration based on contextual similarity.
  • Neural pathways from the vmPFC to the medial entorhinal cortex are key to this regulatory process.
  • Findings offer new insights into the neural basis of memory organization and allocation.