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Updated: Apr 30, 2026
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
Published on: March 4, 2016
Single-Stage Reconstruction with a Bilayer Artificial Dermal Regeneration Matrix for Nasal Skin Malignancies Defects
Huafeng Sun1, Weilin Cai2, Pingping Xu2
1Department of Dermatologic Surgery, Hangzhou Third People's Hospital, No. 38 Xihu Avenue, Hangzhou, 310009, Zhejiang, China. carol007@126.com.
Background:
Nasal reconstruction in Asian patients is challenging given thicker skin, abundant sebaceous glands, and Fitzpatrick skin types III-V, which increase the risk of hypertrophic scarring and pigmentary alterations. Traditional flaps and grafts frequently result in donor-site morbidity, contour deformities, and color mismatch. Conversely, bilayer artificial dermal substitutes offer a potential alternative.
Methods:
This retrospective study included eighteen middle-aged and elderly Chinese patients with nasal skin malignancies (0.5 × 0.5 to 2.3 × 2.6 cm) who underwent standard surgical excision followed by single-stage nasal reconstruction using a bilayer artificial dermis (Lando®). In all cases, intraoperative frozen-section analysis was routinely performed to confirm negative peripheral and deep margins prior to reconstruction. Postoperative management involved routine dressing changes until re-epithelialization. Follow-up was conducted for up to 2 years.
Results:
All defects healed within a mean of 32.67 ± 6.58 days, without requiring secondary grafting or encountering major complications. Minor complications included one superficial infection managed with increased frequency of local wound dressing changes (Clavien-Dindo grade I) and one case of mild hypertrophic scarring that required no additional intervention (Clavien-Dindo grade I). All patients achieved satisfactory wound healing with acceptable nasal contour, and no tumor recurrence was observed during follow-up.
Conclusion:
Single-stage reconstruction using a bilayer artificial dermal substitute is a simple, safe, and effective option for nasal defect repair in Asian patients. It avoids donor-site harvesting, simplifies postoperative management, and may help reduce overall treatment burden, offering a valuable alternative to traditional reconstructive techniques.
Level Of Evidence Iv:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
