Related Experiment Video
Updated: Apr 30, 2026
11:09
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
3.7K
Coronary artery disease imaging with total-body PET
Laura E Clark1, Craig Balmforth1, Matthew Gil2,3
1BHF Centre for Research Excellence, University of Edinburgh, Edinburgh, United Kingdom.
The British Journal of Radiology
|April 28, 2026
Summary
Total-body positron emission tomography (PET) enhances coronary artery imaging, improving sensitivity and signal-to-noise ratios for better coronary artery disease assessment. This advanced technology aids in detecting subtle lesions and understanding systemic disease processes.
Area of Science:
- Cardiovascular Imaging
- Nuclear Medicine
- Medical Technology
Background:
- Coronary artery positron emission tomography (PET) offers insights into coronary artery disease (CAD) and risk stratification.
- Conventional PET systems suffer from low sensitivity and signal-to-noise ratios (SNRs), limiting CAD assessment.
- Technological limitations hinder the comprehensive evaluation of CAD using current PET imaging.
Purpose of the Study:
- To review the current literature on coronary artery PET.
- To explore the application of total-body PET systems in understanding CAD.
- To highlight advancements in PET imaging for cardiovascular disease research.
Main Methods:
- Review of existing scientific literature on coronary artery PET.
- Analysis of the capabilities of total-body PET scanners for cardiovascular imaging.
- Discussion of the impact of enhanced PET sensitivity and resolution on CAD assessment.
Main Results:
- Total-body PET scanners significantly improve sensitivity and effective resolution compared to conventional systems.
- Enhanced imaging facilitates detection of lesions with lower radiotracer uptake.
- Advanced PET systems allow for the unveiling of complex systemic processes in CAD.
Conclusions:
- Total-body PET represents a significant advancement for coronary artery imaging.
- This technology holds promise for improved clinical trial design and drug development in CAD.
- Future research should leverage total-body PET to deepen the understanding of coronary artery disease.
Keywords:
atherosclerosiscoronary artery diseaselong-axial field of viewmolecular imaging (max. 10)positron emission tomographytotal-body PETMore Related Videos
![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
Related Concept Videos
01:28Imaging Studies for Cardiovascular System V: CT
658
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
658
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
720
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
720
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
971
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
971
01:29Positron Emission Tomography
6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
01:20Imaging Studies for Cardiovascular System III: X-Ray
695
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
695
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
853