Innovative approaches to mitigating persistent toxic substances and their impacts on soil health and human well-being

Persistent toxic substances (PTS), including heavy metals, persistent organic pollutants (POPs), and persistent, mobile, and toxic/very persistent and very mobile (PMT/vPvM) substances present an increasing menace to soil health, alimentary systems, atmospheric cleanliness as well as human health. Despite the large amount of literature on each of the individual groups of contaminants, there is still no unified model that connects the dynamics of the soil-atmosphere environment, bioaccumulation in the food chain, new detection techniques, and policy measures. This review presents an interdisciplinary synthesis of dynamics in the PTS in the agricultural environment, explicitly incorporating (i) historic contaminants and emerging PMT/vPvM chemicals, (ii) soil-crop-livestock-human transfer pathways, and (iii) the state-of-the-art remediation and monitoring technologies into a single management framework. We critically evaluated conventional remediation methods alongside next-generation methods, such as engineered consortia of microorganisms, synergistic phytotransformation of plants and microbes, biochar-assisted immobilization, nanosensor-based detection, IoT-based soil sensing, precision agriculture, machine-learning-driven risk prediction, and blockchain-based traceability. Contrary to the previous reviews, which only take into account the remediation, detection, and policy separately, this study presents a systems-based approach, which integrates technological innovation, sustainable agronomic practices, and multilayered governance tools (such as the Stockholm Convention, REACH, and national soil action plans). We highlight the fact that the combination of smart agricultural technology and regenerative land management will help reduce the accumulation of PTS and maintain productivity, especially in resource-scarcity settings. The review outlines the research gaps, including contaminant-microbiome interactions, longitudinal deterioration of ecosystem services, and socioeconomic barriers to technology adoption. We propose a transdisciplinary roadmap that aligns environmental toxicology, soil science, public health, and policy innovation to mitigate PTS and safeguard food security. This integrative approach provides a strategic framework for advancing sustainable management of persistent toxic substances in agricultural systems.