Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

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Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.

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Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib).

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TS and ERCC-1 mRNA expressions and clinical outcome in patients with metastatic colon cancer in CONFIRM-1 and -2 clinical trials.

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Quantitative measurement of relative gene expression in human tumors.

Methods in molecular biology (Clifton, N.J.)·2011

ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine.

Annals of oncology : official journal of the European Society for Medical Oncology·2006

Molecular Rewiring and Compensatory Mechanisms Sustain DNA Recognition in the Mutant ZTA Transcription Factor: Insights from Molecular Dynamics Simulations.

Biochemistry·2026

Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.

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The Photocycle of the Red Light-Sensitive Plant-like Cryptochrome CryP from Phaeodactylum tricornutum.

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Chemical Pathway-Dependent Structural Reorganization at a Hinge Microenvironment in the AcrA Adaptor Protein.

Biochemistry·2026

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions.

Biochemistry·2026

Recognition of Single-Strand-Duplex Junctions in RNA Using Peptide Nucleic Acids That Form Watson-Crick and Hoogsteen Hydrogen Bond.

Biochemistry·2026

A chiral superlattice route to spin-split topological antiferromagnetism.

Nature·2026

Physicochemical Analysis of Coacervates and Premicellar Aggregates in Amino Acid-Based Surfactant Systems.

Journal of oleo science·2026

Humic acid-crosslinked sodium carboxymethyl cellulose/starch superabsorbent polymers: Swelling kinetics, cytotoxicity, and hygiene applications.

Carbohydrate research·2026

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ACS applied materials & interfaces·2026

Control of Helix Screw-Sense Preference in Dynamic Foldamers of meso Symmetry Built From Chiral Monomeric Units.

Angewandte Chemie (International ed. in English)·2026

Anderson-Type Polyoxometalate-Based Covalent Organic Frameworks.

Small (Weinheim an der Bergstrasse, Germany)·2026

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Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

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Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11).

Studies on the mechanism of fluoropyrimidine cytotoxicity in l1210 cells: correlation with inhibition of thymidylate synthetase but not with incorporation into RNA.

Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib).

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Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides

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